Meclizine Wikipedia

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if meclizine is right for you. Through its antagonistic action on the H1 receptors, meclizine primarily works by inhibiting signaling pathway transduction through histaminergic neurotransmission from the vestibular nuclei and NTS to the CTZ and medullary vomiting center. Meclizine may also decrease the labyrinth excitability and vestibular stimulation.

FDA-Labeled Indications and Dosage (Adult)

Before you take this medicine, tell your doctor if you have liver or kidney disease, asthma, glaucoma, an enlarged prostate, or urination problems. You should not take this medication if you are allergic to meclizine. Meclizine is a first-generation antihistamine (nonselective H1 antagonist) of the piperazine class. It is structurally and pharmacologically similar to buclizine, cyclizine, and hydroxyzine.

Another suggests the eyes mostly see the interior of the car which is motionless while the vestibular system of the inner ear senses motion as the vehicle goes around corners or over hills and even small bumps. Therefore, the effect is worse when looking down but may be lessened by looking outside of the vehicle. Common side effects are Drowsiness, dry mouth, and on rare occasions, blurred vision have been reported. Meclizine may trigger drowsiness, fatigue, and dry mouth. In case that happens it is important to immediately contact a physician.

• Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
• The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system.
• You should not use meclizine if you are allergic to it.
• Talk to your healthcare provider about your risks if you are in this age group.
• This effect also reduces vestibular incitation and labyrinth excitability.

Drug Images

Meclizine shows no risk of birth defects or abnormalities when administered during pregnancy. Although Meclizine may excrete into the milk, it causes no harm in nursing babies. Meclizine has a plasma elimination half-life of about 5-6 hours in humans. The volume of distribution of meclizine wikipedia meclizine in humans has not been fully studied.

Meclizine may be taken in the form of tablets, chewable tablets and capsules. When used to prevent motion sickness, they should be taken one hour before the beginning of the trip. Meclizine is an antihistamine, which acts as an antagonist of so-called H1 receptors.

What should I do if I forget a dose?

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use meclizine only for the indication prescribed. Take meclizine exactly as prescribed by your doctor.

Administration and Monitoring

• Symptoms of overdose mainly involve CNS depression with drowsiness, coma, and convulsions.
• Other drugs may interact with meclizine, including prescription and over-the-counter medicines, vitamins, and herbal products.
• Drinking alcohol with this medicine can cause side effects.
• Meclizine may trigger drowsiness, fatigue, and dry mouth.
• There is limited information regarding Meclizine Storage in the drug label.

Histamine H1 receptors are expressed on the vestibular nuclei and nucleus of the solitary tract (NTS) that are activated by motion sickness and stimuli from the pharynx and stomach. When activated, H1 receptor signaling from these nuclei is transmitted to the CTZ and vomiting centre. Meclizine is used to prevent nausea, vomiting, dizziness and motion sickness. Sometimes, it is also used to treat nausea in pregnancy and that triggered by exposure to radiation. Meclizine is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness.

Meclizine side effects

There is limited information regarding Pharmacodynamics of Meclizine in the drug label. There is limited information regarding IV Compatibility of Meclizine in the drug label. There is limited information regarding Monitoring of Meclizine in the drug label. There is limited information regarding Postmarketing Experience of Meclizine in the drug label.

Meclizine has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers.

Stop taking meclizine and get help right away if you have any of the following symptoms of a serious allergic reaction. Using meclizine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. Uncommon (1% to 10%) — Headache, psychomotor impairment, dermatitis, and antimuscarinic effects such as diplopia (double vision), tachycardia, constipation, urinary retention and gastro-intestinal disturbances. While less common, the most serious side effects of meclizine are described below, along with what to do if they happen.

Theaters warned patrons of its possible nauseating effects, cautioning pregnant women in particular. Blair Witch was filmed with a handheld camcorder, which was subjected to considerably more motion than the average movie camera,19 and lacks the stabilization mechanisms of steadicams. For the sake of novelty, IMAX and other panoramic type theaters often show dramatic motions such as flying over a landscape or riding a roller coaster. The sensory conflict theory notes that the eyes view motion while riding in the moving vehicle while other body sensors sense stillness, creating conflict between the eyes and inner ear.